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Antioxidants 9:624

These nanocarriers are often engineered to respond to stroke-specific environmental cues such as local acidosis, oxidative stress, or vascular leakage, to achieve site-specific payload release, thus avoiding systemic side effects like succinate-induced peripheral inflammation or compromised antibacterial defense from systemic itaconate [220]

We propose the following hierarchy: Preparation (Physics): PEMF & Neuro20 : To open cell membranes and mechanically flush lymph, ensuring toxins have an exit route

Similarly, 4-HNE, a highly reactive aldehyde formed during lipid peroxidation, has been implicated in inflammation and aging